Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in Acinetobacter baumannii
Our study provides a molecular characterisation of PmrC and demonstrates the importance of PmrC as a drug target and the strong potential of PmrC binding molecules to act as colistin adjuvants, operating as synergistic tools to combat multiresistant nosocomial pathogens.
Authors
- Eliana De Gregorio (ORCID: https://orcid.org/0000-0002-2529-8611)
- Maria Stabile
- Antonella Migliaccio
- Valeria Napolitano (ORCID: https://orcid.org/0000-0002-6709-8263)
- Flavia Squeglia (ORCID: https://orcid.org/0000-0001-9142-3313)
- Ida Autiero (ORCID: https://orcid.org/0000-0001-8886-8063)
- Federico Falchi (ORCID: https://orcid.org/0000-0001-7385-649X)
- Alessia Ruggiero (ORCID: https://orcid.org/0000-0002-3508-385X)
- Maria Romanò (ORCID: https://orcid.org/0000-0001-8901-3630)
- Rita Berisio
Institutions
- Italian Institute of Technology (IT)
- Institute of Biostructure and Bioimaging (IT)
- National Research Council (IT)
- University of Naples Federico II (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fmicb.2024.1501051
- Citations
- 5
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.85