The effector function of mucosal associated invariant T cells alters with aging and is regulated by RORγt
These results suggest that aging induces a functional shift between MAIT1 and MAIT17 cells, which may be influenced by transcriptional regulators like RORγt. The observed alterations in MAIT cell activity could potentially impact disease prognosis, particularly in colorectal cancer. This study provides new insights into the dynamics of MAIT cell responses at mucosal barriers, highlighting possible therapeutic targets for modulating MAIT cell functions in aging and disease.
Authors
- En Xu (ORCID: https://orcid.org/0000-0003-4874-6373)
- Xing Kang (ORCID: https://orcid.org/0000-0002-8072-015X)
- Zhengxiang He (ORCID: https://orcid.org/0000-0002-8961-859X)
- Minhuan Li (ORCID: https://orcid.org/0000-0003-0560-7533)
- Chuanfu Ren (ORCID: https://orcid.org/0000-0002-1510-1352)
- Banxin Luo
- Xin Chen (ORCID: https://orcid.org/0000-0002-9588-0164)
- Hong Chen (ORCID: https://orcid.org/0000-0002-8146-0943)
- Wenxian Guan (ORCID: https://orcid.org/0000-0002-0207-1705)
- Xuefeng Xia (ORCID: https://orcid.org/0000-0001-8712-4724)
- Zhi Yang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Wuhan University (CN)
- Nanjing Drum Tower Hospital (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1504806
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province