The relationship between anxiety and levels of Alzheimer's disease plasma biomarkers
Anxiety is highly prevalent in Alzheimer's disease (AD), correlating with cerebrospinal fluid/positron emission tomography biomarkers and disease progression. Relationships to plasma biomarkers are unclear. Herein, we compare levels of plasma biomarkers in research participants with and without anxiety at cognitively normal, mild cognitive impairment, and AD dementia stages. We observed significantly higher plasma tau/amyloid-β<sub>42</sub> ratio in AD participants with anxiety versus those without, but did not observe differences at other stages or plasma biomarkers. No such relationships were evident with depression. These results support a unique pathophysiological relationship between anxiety and AD that can be reflected in plasma biomarkers, suggestive of heightened neurodegeneration.
Authors
- Arjun V. Masurkar (ORCID: https://orcid.org/0000-0002-2498-2059)
- Ricardo S. Osorio (ORCID: https://orcid.org/0000-0002-2735-9609)
- Carolina Boza-Calvo (ORCID: https://orcid.org/0000-0002-2048-0668)
- Alok Vedvyas
- Anthony Briggs (ORCID: https://orcid.org/0000-0002-9459-5214)
- Mark A Bernard (ORCID: https://orcid.org/0000-0003-2523-9782)
- Thomas Wısnıewskı (ORCID: https://orcid.org/0000-0002-3379-8966)
- Karyn Marsh (ORCID: https://orcid.org/0009-0003-9057-1551)
- Omonigho M. Bubu (ORCID: https://orcid.org/0000-0001-7438-2628)
- Ludovic Debure
- Wajiha Ahmed (ORCID: https://orcid.org/0009-0007-8121-0307)
- Allal Boutajangout (ORCID: https://orcid.org/0000-0002-9582-5675)
Institutions
- Universidad de Costa Rica (CR)
- Center for Neuro-Oncology (US)
- New York University (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1177/13872877241295324
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Alzheimer's Association
- BrightFocus Foundation
- American Academy of Sleep Medicine
- National Institutes of Health
- National Institute on Aging