The Role of Neurodegeneration in Depression: Inflammatory Responses and Treatment Options

Neurodegeneration has emerged as a significant factor contributing to depression, a prevalent mental health disorder affecting millions worldwide. This article reviews the interplay between neurodegenerative processes and depression, focusing on inflammatory responses that exacerbate this relationship. Evidence suggests that neuroinflammation is a critical mediator in the pathophysiology of depression, linking cognitive decline with mood disturbances. Furthermore, this review discusses various treatment options, including pharmacological and non-pharmacological approaches, emphasizing the importance of addressing underlying neurodegenerative mechanisms to optimize therapeutic outcomes.