Integrated analysis of per- and polyfluoroalkyl substances and plasma lipidomics profiles in multi-ethnic Asian subjects for exposome research
We demonstrate that the circulating levels of PFAS vary with age, ethnicity and sex within a multi-ethnic Asian population with potential implications in future biomonitoring and mitigation. Our comprehensive lipidomics methodology and association studies enabled us to characterize the relationship of circulating PFAS and lipidomic profiles. These results will help in better understanding of the molecular basis of PFAS exposure on human health outcomes.
Authors
- Johan G. Eriksson (ORCID: https://orcid.org/0000-0002-2516-2060)
- Sartaj Ahmad Mir (ORCID: https://orcid.org/0000-0001-6032-0936)
- Anne K. Bendt (ORCID: https://orcid.org/0000-0001-8198-6104)
- Ellie Choi (ORCID: https://orcid.org/0000-0002-2059-3478)
- Kothandaraman Narasimhan (ORCID: https://orcid.org/0000-0002-9287-4260)
- Federico Torta (ORCID: https://orcid.org/0000-0001-7545-7484)
- Nisha Suyien Chandran (ORCID: https://orcid.org/0000-0001-8225-0035)
- Vaitheeswari
Institutions
- Agency for Science, Technology and Research (SG)
- University of Helsinki (FI)
- National University of Singapore (SG)
- Singapore Institute for Clinical Sciences (SG)
- National University Hospital (SG)
- National University Health System (SG)
- Folkhälsans Forskningscentrum (FI)
Publication Details
- Journal
- Environmental Health
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12940-024-01145-4
- Citations
- 5
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Research Foundation
- National University of Singapore