Clinicopathologic characteristics and its association with survival outcomes in gastric cancer after D2 resection followed by S1 and oxaliplatin as adjuvant therapy

There is limited data about the clinic-pathological features and the predictors of survival in gastric cancer patients who received adjuvant SOX post-operation in Vietnam. This study aimed to identify the correlation between clinic-pathological features and clinical outcomes for this population. From January 2019 to December 2023, 69 patients aged above 18 years old were diagnosed with gastric cancer and treated at the National Cancer Hospital Vietnam. Clinical findings, histo-pathological parameters and outcomes were reviewed retrospectively. Clinic-pathological characteristics of the study population showed a predominance of males (60.8%), aged above 60 (52.17%), good performance status, undifferentiated tumour (68.12%), antrum cancers (86.96%), and lymph nodes involvement (75.36 %). The estimated 1-year, 2-year, 3-year overall survival (OS) and disease free survival (DFS) were 92.6%, 77.7%, 74.9% and 80.9%, 72.5% and 72.5%, respectively with the median follow-up period of 17 months. A significant prognostic predictor for survival was the presence of lymph node invasion (p = 0.0167) in a univariate analysis. Gastric cancer patients with adverse prognostic factors (node-positive) have a poor prognoses. Adjuvant chemotherapy may be more beneficial for these patients.