Radioactive iodine therapy dose impact on recurrence and survival in N1 papillary thyroid cancer

Dosages of RAIT ≥ 150 mCi do not appear to provide additional benefit in reducing recurrence compared to doses <150 mCi for N1a or N1b PTC patients. No differences in mortality or immediate RAIT side effects were observed between the two dosing regimens; however, interpretation is limited by low event rates. Large randomized trials are needed for further individualized recommendations regarding optimal RAIT dosage in N1 PTC.

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Publication Details

Journal
Nuclear Medicine Communications
Published
2024-11-27
DOI
https://doi.org/10.1097/mnm.0000000000001936
Primary Topic
Thyroid Cancer Diagnosis and Treatment
Type
article
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article

Radioactive iodine therapy dose impact on recurrence and survival in N1 papillary thyroid cancer

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Radioactive iodine therapy dose impact on recurrence and survival in N1 papillary thyroid cancer

Sapna Nagar, Peter Czako, Fionna Sun, Diane Studzinski, Morta Lapkus, Jordan Reilly, Kevin R. Ward, Jacquelyn Pastewski, Ryan T. Davis, Rose E. Callahan, Heba Elassar, Elizabeth E. Odil
article en

Abstract

Dosages of RAIT ≥ 150 mCi do not appear to provide additional benefit in reducing recurrence compared to doses <150 mCi for N1a or N1b PTC patients. No differences in mortality or immediate RAIT side effects were observed between the two dosing regimens; however, interpretation is limited by low event rates. Large randomized trials are needed for further individualized recommendations regarding optimal RAIT dosage in N1 PTC.

Nuclear Medicine CommunicationsVol. 46(2)
Oakland University (US), GTx (United States) (US), Beaumont Hospital, Royal Oak (US)
Good health and well-being
Openalex Percentile: Top 66%
Thyroid Cancer Diagnosis and Treatment
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