Differential effects of leptin on energy metabolism in murine cell models of metastatic triple negative breast cancer
Taken together, these results demonstrate that at physiological glucose concentrations, leptin increases migration of 4T1 and metM-Wnt<sup>lung</sup> cells via shared and distinct effects on energy metabolism, suggesting that the type of TNBC genetic alteration plays a role in differential metabolic regulation of leptin-induced migration.
Authors
- Marjorie Anne Layosa (ORCID: https://orcid.org/0000-0001-5080-0127)
- Chaylen Andolino (ORCID: https://orcid.org/0000-0001-6836-049X)
- Dorothy Teegarden (ORCID: https://orcid.org/0000-0002-7045-3748)
- Stephen David Hursting (ORCID: https://orcid.org/0000-0003-3605-2833)
- Michael M. Coleman (ORCID: https://orcid.org/0000-0003-4186-3526)
- Chaehyun Yum
Institutions
- University of North Carolina at Chapel Hill (US)
- Purdue University West Lafayette (US)
- Purdue University Institute for Cancer Research
- UNC Lineberger Comprehensive Cancer Center
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s13098-024-01535-1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Agriculture
- Purdue University
- National Institutes of Health