NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice
Activation of the NLRP3-GSDMD pathway in the ileum of Alcoholic liver disease (ALD) mice. NLRP3 activation maintains homeostasis of gut microbiota and intestinal epithelial barrier in ALD mice. ALD mice infected with V. vulnificus infection exhibited no further activation of NLRP3 in the ileum, leading to increased intestinal permeability and bloodstream infections.
Authors
- Yuan Yuan (ORCID: https://orcid.org/0000-0001-7437-7001)
- Guan Yang (ORCID: https://orcid.org/0000-0002-4026-6976)
- Shi‐Qing Li
- Zhiwei Xie (ORCID: https://orcid.org/0000-0001-7302-4132)
- Yi‐Tong Zhang (ORCID: https://orcid.org/0009-0001-8193-6964)
- Jinglin Wang (ORCID: https://orcid.org/0000-0002-7389-1022)
- Bing Yuan (ORCID: https://orcid.org/0009-0007-0160-8420)
- Zisheng Feng
- Jian‐Hao Xu
- Yaru Wang
- Yan Wang (ORCID: https://orcid.org/0009-0002-2584-9337)
Institutions
- Academy of Military Medical Sciences (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Beijing Proteome Research Center (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Ningxia Center for Diseases Prevention and Control (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/ctm2.70099
- Citations
- 9
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.82