<i>Clostridium difficile</i> Bacteremia in an Elderly Patient with Multiple Comorbidities: A Case Report

<i>Clostridium difficile</i> (<i>C. difficile</i>) stands as a primary cause of health-care-associated colitis in adults; however, extraintestinal manifestations of <i>C. difficile</i>, particularly bacteremia, are exceptionally rare. In this report, we document a case of an elderly male with multiple comorbidities who presented with an acute onset of fever. Diagnostic testing revealed the presence of concurrent bacteremia involving <i>C. difficile</i> and <i>Klebsiella pneumonia</i>. The multilocus sequence typing analysis identified this <i>C. difficile</i> strain as ST81. After receiving a combination treatment of vancomycin and biapenem, the patient successfully recovered and was subsequently discharged. This case report elucidates the clinical presentation and treatment strategies for <i>C. difficile</i> ST81 bacteremia, underscoring the critical need for heightened monitoring of extraintestinal infections in high-risk patients.