A Spectroscopy Solution for Contactless Conductivity Detection in Capillary Electrophoresis
This paper introduces a novel contactless single-chip detector that utilizes impedance-to-digital conversion technology to measure impedance in the microfluidic channel or capillary format analytical device. The detector is designed to operate similarly to capacitively coupled contactless conductivity detectors for capillary electrophoresis or chromatography but with the added capability of performing frequency sweeps up to 200 kHz. At each recorded data point, impedance and phase-shift data can be extracted, which can be used to generate impedance versus frequency plots, or phase-shift versus frequency plots. Real and imaginary parts can also be calculated from the data, allowing for the generation of Nyquist diagrams. This detector represents the first of its kind in the contactless conductivity class to provide spectrum-type data, as demonstrated in capillary electrophoresis experiments.
Authors
- Loreta Kubilienė
- Vilma Kaškonienė (ORCID: https://orcid.org/0000-0002-1939-9408)
- Mantas Stankevičius (ORCID: https://orcid.org/0000-0001-5093-1178)
- Kristina Bimbiraitė‐Survilienė (ORCID: https://orcid.org/0000-0001-7021-8062)
- Domantas Armonavičius (ORCID: https://orcid.org/0009-0006-0927-6830)
- Shoji Nagaoka (ORCID: https://orcid.org/0000-0001-8865-6060)
- Elźbieta Skrzydlewska (ORCID: https://orcid.org/0000-0001-5397-7139)
- Yutaka Kuwahara (ORCID: https://orcid.org/0000-0003-2554-6993)
- Audrius Maruška (ORCID: https://orcid.org/0000-0002-9267-3805)
- Linas Jonušauskas (ORCID: https://orcid.org/0000-0002-9360-5118)
- Makoto Takafuji (ORCID: https://orcid.org/0000-0001-9985-2569)
- Tomas Drevinskas (ORCID: https://orcid.org/0000-0002-6932-1457)
- Hirotaka Ihara (ORCID: https://orcid.org/0000-0002-3642-8637)
- Ona Ragažinskienė (ORCID: https://orcid.org/0000-0002-2627-4443)
Institutions
- Lithuanian University of Health Sciences (LT)
- Medical University of Białystok (PL)
- Vytautas Magnus University (LT)
- Kumamoto Industrial Research Institute (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Micromachines
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3390/mi15121430
- Primary Topic
- Microfluidic and Capillary Electrophoresis Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00