Role of <scp>STING</scp> Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis
These findings highlight a pathogenic role of STING and downstream IFN responses in TLR7-driven autoimmunity, vascular damage and atherosclerosis, supporting a therapeutic potential for STING inhibition in SLE treatment. Further research is warranted to elucidate the mechanisms underlying STING's involvement in these processes and to explore the feasibility of targeting STING as a therapeutic strategy in SLE and related autoimmune disorders.
Authors
- Christopher B. Oliveira (ORCID: https://orcid.org/0000-0003-0834-3625)
- Mariana J. Kaplan (ORCID: https://orcid.org/0000-0003-2968-0815)
- Nickie Seto
- Sarfaraz Hasni (ORCID: https://orcid.org/0000-0002-4164-8837)
- Yvonne Baumer (ORCID: https://orcid.org/0000-0001-7400-0773)
- Nehal N. Mehta (ORCID: https://orcid.org/0000-0003-4939-5130)
- Eduardo Patiño‐Martínez (ORCID: https://orcid.org/0000-0002-5986-1257)
- Tiffany M. Powell‐Wiley (ORCID: https://orcid.org/0000-0001-9488-4131)
- Carmelo Carmona‐Rivera (ORCID: https://orcid.org/0000-0002-7706-1464)
- Yudong Liu (ORCID: https://orcid.org/0000-0002-5153-3400)
- Xuan Zhang (ORCID: https://orcid.org/0000-0001-8775-1699)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- National Heart, Lung, and Blood Institute (US)
- National Institute on Minority Health and Health Disparities (US)
- National Center for Clinical Laboratories (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/art.43062
- Citations
- 14
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- National Institutes of Health
- Office of Science
- National Heart, Lung, and Blood Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute on Minority Health and Health Disparities