Transglutaminase 2 inhibition ameliorates cardiac fibrosis in myocardial infarction by inducing M2 macrophage polarization <i>in vitro</i> and <i>in vivo</i>
TG2 inhibition facilitated M2 macrophage polarization to provide protection against MI-caused cardiac fibrosis in mice, and these effects may be attained through modulation of the TGF-β1/Smad3 pathway.
Authors
- Alimujiang Maimaitijiang (ORCID: https://orcid.org/0000-0002-4351-2992)
- Shengjia Sun (ORCID: https://orcid.org/0000-0002-4253-3046)
- Yurong Wu (ORCID: https://orcid.org/0000-0002-1841-3749)
- Qingyu Huang (ORCID: https://orcid.org/0000-0002-5076-2084)
- Qiying Chen (ORCID: https://orcid.org/0000-0003-3118-2129)
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-11-28
- DOI
- https://doi.org/10.25259/cytojournal_32_2024
- Citations
- 5
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Shanghai Municipal Health Commission