Biocatalysis: modern challenges and applications
The review analyzes recent advances, challenges, and practical applications in the field of enzymes within the framework of chemical enzymology and enzyme engineering. The achievements in the fundamental understanding of molecular mechanisms of the catalytic cycle of enzymatic reactions made using quantum mechanics/molecular mechanics methods with supercomputer technologies and bioinformatic approaches are considered. The design of protein biocatalysts with new properties is a fundamentally significant methodology of the bioengineering approach to solving practical problems, which is demonstrated by a number of examples. The increasing role of biocatalysis in medicine and biomedical research is illustrated by addressing the problems of antibiotic synthesis and overcoming antibiotic resistance of bacteria, mechanisms of neurodegenerative diseases and development of drugs to treat Alzheimer's disease, biocatalytic processes of DNA repair and the role of mechanisms of functioning of heme peroxidases in the human body. The use of enzymes to degrade endogenous and exogenous toxicants has been greatly developed in recent decades. The advances and problems of using enzymes in therapy and drug delivery are analyzed. The fundamental role of enzymes in modern analysis and diagnosis is noted. The review considers a new trend in the development of bioanalytical methods using aptamers, multi-analysis systems on biochips, surface-enhanced Raman scattering systems, and bioelectroanalysis. <br>The bibliography includes 460 references.
Authors
- Olga I. Lavrik (ORCID: https://orcid.org/0000-0001-5980-8889)
- А. М. Рожкова (ORCID: https://orcid.org/0000-0003-4901-4705)
- О. А. Кост (ORCID: https://orcid.org/0000-0001-9665-0523)
- Anton V. Lopukhov (ORCID: https://orcid.org/0000-0002-3517-505X)
- Alexander A. Baykov (ORCID: https://orcid.org/0000-0002-2495-8200)
- О. М. Панасенко (ORCID: https://orcid.org/0000-0001-5245-2285)
- Н.Н. Угарова (ORCID: https://orcid.org/0000-0003-3764-4689)
- Patrick Masson (ORCID: https://orcid.org/0000-0002-7837-3662)
- D. L. Atroshenko (ORCID: https://orcid.org/0000-0003-2100-4118)
- Rami A. Masamrekh (ORCID: https://orcid.org/0000-0002-9964-8717)
- I. V. Gachok (ORCID: https://orcid.org/0000-0002-5035-112X)
- L.E. Agafonova (ORCID: https://orcid.org/0000-0003-3874-6556)
- С. О. Бачурин (ORCID: https://orcid.org/0000-0003-3637-818X)
- Larisa V. Sigolaeva (ORCID: https://orcid.org/0000-0002-2477-0793)
- Evgeniy G. Evtushenko (ORCID: https://orcid.org/0000-0003-1264-4770)
- Tatiana A. Filippova (ORCID: https://orcid.org/0000-0001-9992-0074)
- Polina I. Koroleva (ORCID: https://orcid.org/0000-0003-2802-5747)
- I. A. Ryzhikov (ORCID: https://orcid.org/0000-0002-9432-9442)
- Azizbek D. Usvaliev (ORCID: https://orcid.org/0000-0002-2417-8984)
- Е. В. Попова (ORCID: https://orcid.org/0000-0002-2419-2823)
- Irina M. Le‐Deygen (ORCID: https://orcid.org/0000-0002-6366-4491)
- Natalia L. Klyachko (ORCID: https://orcid.org/0000-0002-9357-8236)
- Vytas K. Švedas (ORCID: https://orcid.org/0000-0002-1664-0307)
- Maria G. Khrenova (ORCID: https://orcid.org/0000-0001-7117-3089)
- Dmitry V. Pergushov (ORCID: https://orcid.org/0000-0002-1344-1791)
- Maria I. Zvereva (ORCID: https://orcid.org/0000-0002-7432-1574)
- Victoria V. Shumyantseva (ORCID: https://orcid.org/0000-0002-1509-7218)
- I. A. Boginskaya (ORCID: https://orcid.org/0000-0001-6992-8876)
- Галина Ф. Махаева (ORCID: https://orcid.org/0000-0002-8136-6906)
- Margarita O. Shleeva (ORCID: https://orcid.org/0000-0001-7286-9336)
- Еlena V. Kudryashova (ORCID: https://orcid.org/0000-0002-9761-7757)
- M. Yu. Rubtsova (ORCID: https://orcid.org/0000-0003-4025-5967)
- Alexander P. Savitsky (ORCID: https://orcid.org/0000-0002-6820-2341)
- Dmitry O. Zharkov (ORCID: https://orcid.org/0000-0001-5013-0194)
- Zukhra Shaihutdinova (ORCID: https://orcid.org/0009-0008-5713-4137)
- Ilya D. Solovyev (ORCID: https://orcid.org/0000-0002-6580-9615)
- E. A. Slipchenko (ORCID: https://orcid.org/0000-0002-1742-8308)
- Maxim M. Veselov (ORCID: https://orcid.org/0000-0002-8983-2772)
- А. П. Синицын (ORCID: https://orcid.org/0000-0001-6429-8254)
- G. Yu. Lomakina (ORCID: https://orcid.org/0000-0002-8156-0848)
- Elena N. Efremenko (ORCID: https://orcid.org/0000-0002-6992-854X)
- A. A. Pometun (ORCID: https://orcid.org/0000-0003-4344-0869)
- С. Д. Варфоломеев
- О. А. Синицына (ORCID: https://orcid.org/0000-0001-5424-7402)
- Ilya Lyagin (ORCID: https://orcid.org/0000-0002-3970-4334)
- Vladimir I. Muronetz (ORCID: https://orcid.org/0000-0001-7838-3089)
- А.М. Егоров (ORCID: https://orcid.org/0000-0003-3531-6219)
- С. С. Савин (ORCID: https://orcid.org/0000-0002-0788-2507)
- N. K. Marynich (ORCID: https://orcid.org/0000-0003-1032-0959)
- G. V. Presnova (ORCID: https://orcid.org/0000-0001-9598-4548)
- В. И. Тишков (ORCID: https://orcid.org/0000-0002-6997-7229)
- Marina Sedova (ORCID: https://orcid.org/0000-0002-3213-1609)
- Maria M Ulyashova (ORCID: https://orcid.org/0000-0002-3837-4759)
- Alexey V. Kuzikov (ORCID: https://orcid.org/0000-0002-8772-3214)
- Anna V. Yudkina (ORCID: https://orcid.org/0000-0003-3682-3431)
- Tatiana N. Pashirova (ORCID: https://orcid.org/0000-0002-2001-1570)
- Victoria Tikhomirova (ORCID: https://orcid.org/0000-0003-4368-3430)
- Natalia V. Dobryakova (ORCID: https://orcid.org/0009-0004-4405-725X)
- Iuliia V. Chudosai
- Olga V. Kryukova
- Tatiana V. Bulko
- Н. Л. Еремеев (ORCID: https://orcid.org/0000-0002-1354-490X)
- Ilya N. Kurochkin (ORCID: https://orcid.org/0000-0002-2631-5866)
- Yu. Yu. Zvyagina
Institutions
- Russian Academy of Sciences (RU)
- Bauman Moscow State Technical University (RU)
- Lomonosov Moscow State University (RU)
- Kazan Federal University (RU)
- Pirogov Russian National Research Medical University (RU)
- Institute of Chemical Biology and Fundamental Medicine (RU)
- Siberian Branch of the Russian Academy of Sciences (RU)
- A.E. Arbuzov Institute of Organic and Physical Chemistry (RU)
- Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU)
- Institute of Biochemical Physics NM Emanuel (RU)
- Institute of Biomedical Chemistry (RU)
- Institute of Theoretical and Applied Electrodynamics (RU)
- Institute of Physiologically Active Compounds (RU)
- Federal Medical-Biological Agency (RU)
Publication Details
- Journal
- Russian Chemical Reviews
- Published
- 2024-11-28
- DOI
- https://doi.org/10.59761/rcr5144
- Citations
- 5
- Primary Topic
- Enzyme Catalysis and Immobilization
- Type
- article
- Field-Weighted Citation Impact
- 1.17