Taprenepag restores maternal–fetal interface homeostasis for the treatment of neurodevelopmental disorders
Taprenepag improved autism-like behaviors in the offspring of VPA-exposed mice by addressing placental IDO-1 downregulation. This study highlights the potential of targeting IDO-1 to mitigate MFI disruption and NDD development.
Authors
- Fuqiang Hu
- Hong Yuan (ORCID: https://orcid.org/0000-0002-0535-3214)
- Tingting Meng
- Xu Yi‐chong (ORCID: https://orcid.org/0000-0001-6823-8013)
- Xiaomei Wu (ORCID: https://orcid.org/0000-0002-7425-8755)
- Xiangyu Jin (ORCID: https://orcid.org/0000-0002-9277-7583)
- Yunxia Wang (ORCID: https://orcid.org/0000-0003-1951-942X)
- Sufen Li (ORCID: https://orcid.org/0000-0002-2695-8263)
- Ke Jia (ORCID: https://orcid.org/0000-0002-7243-7792)
- Yiling Hong (ORCID: https://orcid.org/0000-0003-4491-0762)
- Lijuan Wen (ORCID: https://orcid.org/0000-0001-8070-0338)
- Kai Wang (ORCID: https://orcid.org/0000-0002-6151-0034)
- Shufen Zhang
Institutions
- Zhejiang Cancer Hospital (CN)
- Gannan Medical University (CN)
- Jinhua Academy of Agricultural Sciences (CN)
- University of Chinese Academy of Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12974-024-03300-7
- Citations
- 1
- Primary Topic
- Maternal Mental Health During Pregnancy and Postpartum
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Zhejiang University
- Natural Science Foundation of Zhejiang Province