Successful Pregnancy in a Poor Responder: Natural In Vitro Fertilization, Menopause Treatment With Oral Contraceptives, and Anti-Müllerian Hormone as a Predictor

The study focuses on spontaneous conception after menopause in a woman with primary ovarian insufficiency (POI), with an emphasis on the role of anti-Müllerian hormone (AMH) in fertility management. This case involves a 33-year-old woman with POI who has experienced both aided and spontaneous pregnancies. She had low AMH and high follicle-stimulating hormone (FSH) levels, which typically indicate a limited ovarian reserve. Despite several unsuccessful in vitro fertilization (IVF) attempts, she ultimately conceived using a modified natural cycle (MNC). Later, while on oral contraception and nearing menopause, she conceived spontaneously, resulting in a viable pregnancy. This case highlights the unpredictability of POI, the relevance of AMH as a biomarker of ovarian reserve, and the potential for spontaneous conception even after menopause, emphasizing the need for individualized reproductive treatments in managing POI patients.