Phytochemical profiling and in silico evaluation of Artemisia absinthium compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analyses
The findings of this study underscore the potential of Artemisia absinthium compounds, particularly apigenin, as promising candidates for the development of new anti-leishmaniasis drugs. The potent inhibition of Leishmania NMT by apigenin, along with its favorable pharmacokinetic and stability profiles, supports its further exploration in antileishmanial drug development.
Authors
- Ahmed Barhoum
- Farouk Boudou (ORCID: https://orcid.org/0000-0002-6008-3325)
- Amal Belakredar (ORCID: https://orcid.org/0000-0003-0997-690X)
- Mikhaël Bechelany (ORCID: https://orcid.org/0000-0002-2913-2846)
- Huda Alsaeedi
- David Cornu (ORCID: https://orcid.org/0000-0002-5205-3038)
- Alaeddine Berkane
- Ahcen Keziz
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- Université de Mostaganem (DZ)
- Gulf University for Science & Technology (KW)
- King Saud University (SA)
- Université Djilali de Sidi Bel Abbès (DZ)
- University Mohamed Boudiaf of M'sila (DZ)
- Université de Saida Dr.Moulay Tahar (DZ)
- Institut Européen des Membranes (FR)
- Helwan University (EG)
Publication Details
- Journal
- Frontiers in Chemistry
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fchem.2024.1508603
- Citations
- 10
- Primary Topic
- Research on Leishmaniasis Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.43
Funders
- King Saud University