Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation
We discover direct interactions between PKAC and two domains in Ca<sub>V</sub>1.2α<sub>1</sub>. We propose that these tripartite interactions, if present in vivo, may participate in organizing the multimolecular signaling complex and fine-tuning the βAR effect in cardiomyocytes.
Authors
- Sharon W. Weiss (ORCID: https://orcid.org/0000-0002-0981-6917)
- Friedrich W. Herberg (ORCID: https://orcid.org/0000-0001-7117-7653)
- Vladimir Tsemakhovich (ORCID: https://orcid.org/0000-0002-4969-6497)
- Debi Ranjan Tripathy (ORCID: https://orcid.org/0000-0002-6842-0138)
- Shimrit Oz (ORCID: https://orcid.org/0000-0001-5110-3833)
- Tal Keren‐Raifman
- Leonid Vysochek
- Joel A. Hirsch (ORCID: https://orcid.org/0000-0001-7544-8668)
- Enno Klußmann (ORCID: https://orcid.org/0000-0003-4004-5003)
- Anastasiia Sholokh (ORCID: https://orcid.org/0000-0002-1263-2078)
- Claudia Fecher‐Trost (ORCID: https://orcid.org/0000-0002-8799-4188)
- Nathan Dascal (ORCID: https://orcid.org/0000-0002-5397-4146)
- Veit Flockerzi (ORCID: https://orcid.org/0000-0001-6002-6294)
- Moshe Katz (ORCID: https://orcid.org/0000-0002-0327-3026)
- Kerstin Zühlke
- Tamara Pallien
- Orna Chomsky-Hecht (ORCID: https://orcid.org/0000-0001-7329-9785)
- Suraj Subramaniam (ORCID: https://orcid.org/0000-0001-9574-2100)
- Daniela Bertinetti (ORCID: https://orcid.org/0000-0003-1150-3765)
- Tom Sharon
- Giorgia Sasson
- Maike Schulz-Christian
- Baraa Watad
Institutions
- University of Kassel (DE)
- Tel Aviv University (IL)
- National Institute of Technology Agartala (IN)
- Max Delbrück Center (DE)
- Sheba Medical Center (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
- German Centre for Cardiovascular Research (DE)
- Saarland University (DE)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12915-024-02076-9
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Deutsche Forschungsgemeinschaft
- Else Kröner-Fresenius-Stiftung