Whole-genome DNA methylomes of tree shrew brains reveal conserved and divergent roles of DNA methylation on sex chromosome regulation
Our study offers novel information on genomic DNA methylation of tree shrews as well as insights into the evolution of sex chromosome regulation in mammals. Specifically, we show conserved role of DNA methylation in regulation of Xist expression and propose genomic CpG contents as a factor in driving sex-differential DNA methylation of X-linked promoters.
Authors
- Ting Hu (ORCID: https://orcid.org/0000-0001-6382-0602)
- Soojin V. Yi (ORCID: https://orcid.org/0000-0003-1497-1871)
- Yulian Tan
- Lei Shi (ORCID: https://orcid.org/0000-0003-3583-4649)
- Yifan Kong
- Dongmin R. Son
Institutions
- Kunming Institute of Botany (CN)
- Kunming University (CN)
- University of California, Santa Barbara (US)
- Kunming Institute of Zoology (CN)
- Chinese Academy of Sciences (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12915-024-02071-0
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Science Foundation
- Kunming Science and Technology Bureau
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- National Institutes of Health
- University of California, Santa Barbara
- Kunming Institute of Zoology, Chinese Academy of Sciences
- National Key Research and Development Program of China
- California NanoSystems Institute