Highly efficient generation of mature megakaryocytes and functional platelets from human embryonic stem cells
Thus, our results demonstrated that we successfully established a highly efficient differentiation of hESCs into mature MKs and functional platelets in vitro. The in vivo functionality of hESC-derived platelets closely resembles that of natural human platelets, thus offering a promising avenue for the development of functional platelets suitable for future clinical applications.
Authors
- Haibin Wu (ORCID: https://orcid.org/0000-0001-8628-4232)
- Yaming Wei (ORCID: https://orcid.org/0000-0001-7218-0563)
- Chuxin Chen (ORCID: https://orcid.org/0000-0002-0008-5302)
- Yingjie Fu
- Yuyou Duan (ORCID: https://orcid.org/0000-0002-1402-7402)
- Ning Wang (ORCID: https://orcid.org/0000-0003-1410-329X)
- Xueyan Zhang
- Zhiyong Zhong (ORCID: https://orcid.org/0000-0003-1127-4915)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou Blood Center (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s13287-024-04071-x
- Citations
- 4
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.82