Electrochemical Dichlorinative Cyclization of 1,<i>n</i>-Enynes by 4-Iodotoluene Catalysis
An electrochemical approach for the indirect oxidative generation of hypervalent iodoarene as a reaction catalyst has been reported. The reaction proceeds first from the generation of active Cl species by electro-oxidation, followed by oxidative transfer to generate ArICl<sub>2</sub>, which subsequently reacts with enynes to achieve cyclization. This protocol provides a simple and green method for accessing dichlorinative cyclization products in high yields with good selectivity.
Authors
- Longji Li (ORCID: https://orcid.org/0009-0009-2445-1846)
- Yang’en You (ORCID: https://orcid.org/0009-0004-2945-7079)
- Xingmin Han
- Zhongjian Du
- Xu Wang (ORCID: https://orcid.org/0000-0002-2092-4054)
Institutions
- Hefei University of Technology (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1021/acs.orglett.4c04041
- Citations
- 5
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.25
Funders
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- Natural Science Foundation of Henan Province
- Anhui Postdoctoral Science Foundation
- Natural Science Foundation of Anhui Province
- Fundamental Research Funds for the Central Universities