Intracranial hemorrhage in an infant leads to the diagnosis and treatment of severe hemophilia B: a case report

This is an uncommon case in which rFIXFc was continued despite the appearance of an allergic reaction and the development of FIX inhibitors. Subsequent allergic reactions were prevented with a combination of oral oxatomide and intravenous hydrocortisone given prior to prophylactic rFIXFc. Further studies are recommended to determine the usefulness of this combination with rFIX therapy.

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Publication Details

Journal
˜The œItalian Journal of Pediatrics/Italian journal of pediatrics
Published
2024-11-28
DOI
https://doi.org/10.1186/s13052-024-01819-2
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
0.00

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article

Intracranial hemorrhage in an infant leads to the diagnosis and treatment of severe hemophilia B: a case report

Valentina Palladino, Giuseppe Lassandro, Paola Giordano
˜The œItalian Journal of Pediatrics/Italian journal of pediatrics
Hemophilia Treatment and Research
article

Intracranial hemorrhage in an infant leads to the diagnosis and treatment of severe hemophilia B: a case report

Valentina Palladino, Giuseppe Lassandro, Paola Giordano
article en

Abstract

This is an uncommon case in which rFIXFc was continued despite the appearance of an allergic reaction and the development of FIX inhibitors. Subsequent allergic reactions were prevented with a combination of oral oxatomide and intravenous hydrocortisone given prior to prophylactic rFIXFc. Further studies are recommended to determine the usefulness of this combination with rFIX therapy.

˜The œItalian Journal of Pediatrics/Italian journal of pediatricsVol. 50(1)
University of Bari Aldo Moro (IT)
Swedish Orphan Biovitrum
Good health and well-being
Openalex Percentile: Top 65%
Hemophilia Treatment and Research
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