Macular Amyloidosis, A Type of Pigmentation in Atopic Dermatitis that is Pathogenically Related

Background Macular amyloidosis (MA) is a chronic pruritic skin condition characterized by hyperpigmentation, primarily affecting the back and extensor surfaces of the extremities. The exact etiology remains unknown; however, genetic and environmental factors, such as chronic friction, appear to play a role. An association between atopic dermatitis and cutaneous amyloidosis has been reported. Methods This study evaluates the prevalence of atopy in 40 patients diagnosed with MA. Results Atopic dermatitis, asthma, and allergic rhinitis were observed in 20%, 8%, and 20% of patients, respectively. A positive family history of atopy was noted in 90% of patients. Pruritus was significantly more severe in patients with atopic dermatitis (p-value = 0.003). Conclusions We recommend considering both personal and family histories of atopy when assessing patients with MA