1,2-Oxidative Trifluoromethylation of Olefin with Ag(O2CCF2SO2F) and O2: Synthesis of α-Trifluoromethyl Ketones
A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O<sub>2</sub>CCF<sub>2</sub>SO<sub>2</sub>F) as a trifluoromethyl source is described with O<sub>2</sub> as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
Authors
- Wangchuan Xiao
- Shengxue Zhang (ORCID: https://orcid.org/0009-0006-9511-2364)
- Yafei Shi (ORCID: https://orcid.org/0000-0003-0247-2098)
- Fanhong Wu (ORCID: https://orcid.org/0000-0003-4483-4712)
- Jingjing Wu (ORCID: https://orcid.org/0000-0002-5733-7670)
- Houjin Huang (ORCID: https://orcid.org/0000-0002-3700-318X)
- Chao Liu (ORCID: https://orcid.org/0000-0003-1968-031X)
- Xiaoyu Ma (ORCID: https://orcid.org/0000-0002-0188-4210)
Institutions
- Jingdong (China) (CN)
- Shanghai Institute of Organic Chemistry (CN)
- University of Chinese Academy of Sciences (CN)
- Shanghai Institute of Technology (CN)
Publication Details
- Journal
- Molecules
- Published
- 2024-11-27
- DOI
- https://doi.org/10.3390/molecules29235622
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Shanghai Institute of Technology