Mucosal vaccination with outer membrane vesicles derived from Bordetella pertussis reduces nasal bacterial colonization after experimental infection
All the experiments presented here demonstrate that the use of OMVs, regardless of the scheme applied (except for OMV<sub>SL-SL</sub>), significantly outperformed acellular pertussis (aP) vaccines, achieving a higher reduction in bacterial colonization in the upper respiratory tract (p<0.01).
Authors
- Daniela Bottero
- Thomas Ebensen (ORCID: https://orcid.org/0000-0001-8906-063X)
- Erika Rudi
- Carlos A. Guzmán (ORCID: https://orcid.org/0000-0002-2913-5254)
- Elizabeth R. Gaillard (ORCID: https://orcid.org/0000-0002-2791-7762)
- Daniela Hozbor (ORCID: https://orcid.org/0000-0001-6379-0482)
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Helmholtz Centre for Infection Research (DE)
- Instituto de Biotecnología y Biología Molecular (AR)
- Universidad Nacional de La Plata (AR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3389/fimmu.2024.1506638
- Citations
- 5
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 1.72