Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Both dose-related and non-dose-related AC burden scores have limited sensitivity and modest PPV for screening a patient's medication for POD. However, given the additional effort required for dose consideration, the non-dose-related GerACB remains sufficient in clinical practice, with the lowest sensitivity but highest PPV.
Authors
- Dorothea Strobach (ORCID: https://orcid.org/0000-0003-2871-0605)
- Carolin Geßele (ORCID: https://orcid.org/0009-0000-1593-0938)
- Konstantinos A. Dimitriadis (ORCID: https://orcid.org/0000-0003-0417-2267)
- Thomas Saller (ORCID: https://orcid.org/0000-0003-3987-6272)
- Ute Amann (ORCID: https://orcid.org/0000-0001-5913-6031)
- Vera Smolka
- Constanze Rémi (ORCID: https://orcid.org/0000-0001-7655-0306)
Institutions
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Drugs & Aging
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1007/s40266-024-01159-0
- Citations
- 3
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.27
Funders
- Ludwig-Maximilians-Universität München