Basic and preclinical epilepsy research Scientists' perception of clinical epileptology

The interaction between basic science epilepsy researchers and clinical epileptologists is a longstanding issue. Efforts to provide opportunities for a dialogue between preclinical and clinical epilepsy professionals are crucial to reduce the knowledge gap between them and improve the translational success of neurobiology-based research. The International League Against Epilepsy (ILAE) Research and Innovation Task Force circulated a survey to investigate the need for an update on new clinical epilepsy concepts within the basic science community. The 336 respondents included basic scientists (BS), preclinical scientists (PCSs), and/or clinical scientists (CSs). The majority of the 237 BSs/PCSs were engaged in preclinical studies in translational epilepsy research and declared translational research as a priority research interest. Fewer respondents from low-middle-income countries than from upper-middle or high-income countries (40.7% vs 65%) considered translational research a critical aspect of their research. A broad understanding of both clinical and neurobiological aspects of epilepsy was declared by 48% of BSs/PCSs; 96% of CSs declared a superficial knowledge of neurobiology of epilepsy. Most BSs/PCSs were aware that epilepsy is a complex condition that should be investigated with the help of clinical epileptologists, even though concerns were expressed on the relationship with clinicians. A focused training program on emerging clinical epileptological aspects tailored for BSs/PCSs was recommended by 81% of the participants; the majority of respondents preferred either 1- or 2-week in-presence tutoring or continuous online training coordinated by ILAE at the regional/national level. The survey also underscored the value of educational programs on neurobiology of epilepsy targeting CSs and low-middle-income countries (LMIC) investigators.

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Publication Details

Journal
Epilepsia
Published
2024-11-28
DOI
https://doi.org/10.1111/epi.18186
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Basic and preclinical epilepsy research Scientists' perception of clinical epileptology

Judith Helen Cross, Jo M. Wilmshurst, Piero Perucca, Jennifer N. Gelinas et al.
Epilepsia
Epilepsy research and treatment
article

Basic and preclinical epilepsy research Scientists' perception of clinical epileptology

Judith Helen Cross, Jo M. Wilmshurst, Piero Perucca, Jennifer N. Gelinas, Marco de Curtis, Ésper A. Cavalheiro, William D. Gaillard, Heidrun Potschka, Fernando Cendes, Aristea S. Galanopoulou, Melody Asukile, Francesco Deleo, Chahnez Triki, Akio Ikeda, Marian Galovic, Luísa Rocha, Manisha Patel, Giulia Battaglia, Annabelle Sellin
article en

Abstract

The interaction between basic science epilepsy researchers and clinical epileptologists is a longstanding issue. Efforts to provide opportunities for a dialogue between preclinical and clinical epilepsy professionals are crucial to reduce the knowledge gap between them and improve the translational success of neurobiology-based research. The International League Against Epilepsy (ILAE) Research and Innovation Task Force circulated a survey to investigate the need for an update on new clinical epilepsy concepts within the basic science community. The 336 respondents included basic scientists (BS), preclinical scientists (PCSs), and/or clinical scientists (CSs). The majority of the 237 BSs/PCSs were engaged in preclinical studies in translational epilepsy research and declared translational research as a priority research interest. Fewer respondents from low-middle-income countries than from upper-middle or high-income countries (40.7% vs 65%) considered translational research a critical aspect of their research. A broad understanding of both clinical and neurobiological aspects of epilepsy was declared by 48% of BSs/PCSs; 96% of CSs declared a superficial knowledge of neurobiology of epilepsy. Most BSs/PCSs were aware that epilepsy is a complex condition that should be investigated with the help of clinical epileptologists, even though concerns were expressed on the relationship with clinicians. A focused training program on emerging clinical epileptological aspects tailored for BSs/PCSs was recommended by 81% of the participants; the majority of respondents preferred either 1- or 2-week in-presence tutoring or continuous online training coordinated by ILAE at the regional/national level. The survey also underscored the value of educational programs on neurobiology of epilepsy targeting CSs and low-middle-income countries (LMIC) investigators.

EpilepsiaVol. 66(1)
Albert Einstein College of Medicine (US), Children's National (US), University of Sfax (TN), University of Cape Town (ZA), Universidade Estadual de Campinas (UNICAMP) (BR), University of Zurich (CH), Kyoto University (JP), Columbia University Irving Medical Center (US), University of Zambia (ZM), University Hospital of Zurich (CH), Hopital Universitaire Hedi Chaker (TN), International League Against Epilepsy (US), Red Cross War Memorial Children's Hospital (ZA), Austin Health (AU), Fondazione IRCCS Istituto Neurologico Carlo Besta (IT), University College London (GB), University of Colorado Anschutz Medical Campus (US), University of Montana (US), Ludwig-Maximilians-Universität München (DE), Universidade Federal de São Paulo (BR)
U.S. Department of Defense, National Institute of Neurological Disorders and Stroke
Openalex Percentile: Top 71%
Epilepsy research and treatment
DOIOpen Access PDFOpenAlex
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