TbpB-based oral mucosal vaccine provides heterologous protection against Glässer’s disease caused by different serovars of Spanish field isolates of Glaesserella parasuis
This study demonstrates that oral mucosal administration of the TbpB<sup>Y167A</sup> subunit vaccine in piglets provides effective heterologous protection against diverse virulent European G. parasuis field isolates, significantly reducing bacterial colonization and dissemination. This vaccine offers a promising alternative to traditional bacterins, overcoming limitations due to maternal immunity, and represents a strong candidate for universal vaccination against Glässer's disease.
Authors
- César B. Gutiérrez‐Martín (ORCID: https://orcid.org/0000-0001-5312-3854)
- María José García Iglesias (ORCID: https://orcid.org/0000-0002-7786-6561)
- Sonia Martínez-Martínez (ORCID: https://orcid.org/0000-0002-2338-7776)
- Máximo Petrocchi-Rilo (ORCID: https://orcid.org/0000-0001-6723-714X)
- Óscar Mencía‐Ares (ORCID: https://orcid.org/0000-0002-9923-2623)
- Elena Herencia-Lagunar
- Rubén Miguélez-Pérez
- Vanessa Acebes-Fernández
- Alba González-Fernández (ORCID: https://orcid.org/0000-0003-1306-4137)
- Alberto Perelló-Jiménez
Institutions
- Instituto de Investigación en Recursos Cinegéticos (ES)
- Universidad de León (ES)
Publication Details
- Journal
- Porcine Health Management
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s40813-024-00404-7
- Citations
- 2
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
- Ministerio de Ciencia e Innovación
- Junta de Castilla y León
- Universidad de León
- Agencia Estatal de Investigación