Ablation of <scp>CCL17</scp>‐positive hippocampal neurons induces inflammation‐dependent epilepsy
In conclusion, our data demonstrate that sterile pyramidal neuronal death is sufficient to cause epilepsy in the absence of other pathological processes. The CCL17-DTR mouse line may thus be a valuable model for further mechanistic studies on epilepsy and assessment of antiseizure medication.
Authors
- John P. Eberhard (ORCID: https://orcid.org/0009-0000-3445-6397)
- Konrad Knöpper (ORCID: https://orcid.org/0000-0003-2076-2160)
- Heike Weighardt (ORCID: https://orcid.org/0000-0002-3810-5890)
- Lorenz Fülle (ORCID: https://orcid.org/0000-0003-2087-2984)
- Frederic Brosseron (ORCID: https://orcid.org/0000-0003-3137-7516)
- Lea Hänschke (ORCID: https://orcid.org/0000-0003-3964-6581)
- Jana Böhringer
- Matthias Lochner (ORCID: https://orcid.org/0000-0002-7979-5613)
- Lukas Henning (ORCID: https://orcid.org/0000-0003-4749-5162)
- Christian Steinhäuser (ORCID: https://orcid.org/0000-0003-2579-8357)
- Frederike J. Graelmann (ORCID: https://orcid.org/0000-0002-6265-3547)
- Ana I. Domingos (ORCID: https://orcid.org/0000-0002-7938-4814)
- Stefanie Eyerich (ORCID: https://orcid.org/0000-0002-1166-2355)
- Peter Bedner (ORCID: https://orcid.org/0000-0003-0090-7553)
- Irmgard Förster (ORCID: https://orcid.org/0000-0002-7644-5642)
- Michael T. Heneka (ORCID: https://orcid.org/0000-0003-4996-1630)
- Julia Kenzler
Institutions
- Howard Hughes Medical Institute (US)
- University of Bonn (DE)
- University of California, San Francisco (US)
- University of Luxembourg (LU)
- German Center for Neurodegenerative Diseases (DE)
- Helmholtz Zentrum München (DE)
- Medizinische Hochschule Hannover (DE)
- University of Oxford (GB)
- Sanofi (Germany) (DE)
- Institute of Medical Microbiology and Hygiene (DE)
- Technical University of Munich (DE)
- Deutsche Forschungsgemeinschaft (DE)
Publication Details
- Journal
- Epilepsia
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1111/epi.18200
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Pfizer
- Deutsche Forschungsgemeinschaft
- Weizmann Institute of Science
- Deutsches Zentrum für Neurodegenerative Erkrankungen
- National Institutes of Health
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council
- European Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases