Relationship between physical activity and biomarkers of pathology and neuroinflammation in preclinical autosomal‐dominant Alzheimer's disease
Locomotion (average steps) was not associated with plasma biomarkers or cognition.Greater training load (training impulse) was related to higher glial fibrillary acidic protein levels in mutation carriers.Light physical activity may not suffice to exert a protective effect on Alzheimer's disease.
Authors
- Glen Picard
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- J. Andrew Taylor (ORCID: https://orcid.org/0000-0003-2802-4330)
- Edmarie Guzmán‐Vélez (ORCID: https://orcid.org/0000-0002-3076-0727)
- Francisco Lopera (ORCID: https://orcid.org/0000-0002-5238-0231)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Sofia Fabrega
- Steven E. Arnold
- Jairo E. Martínez (ORCID: https://orcid.org/0000-0002-5888-481X)
- Gabriel Melo de Oliveira (ORCID: https://orcid.org/0000-0002-6766-3613)
- Angelys Rivera‐Hernández (ORCID: https://orcid.org/0009-0009-9039-8887)
Institutions
- Boston University (US)
- Harvard University (US)
- University of Puerto Rico at Río Piedras (PR)
- Spaulding Rehabilitation Hospital (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Spaulding Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/trc2.70003
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Massachusetts General Hospital
- Biogen
- National Institutes of Health
- National Institute on Aging