Investigation of the Antimicrobial Activities of Schiff Bases Containing Triazoles

Objective: Pathogen parasites and bacteria are microorganisms that have existed throughout human history and cause different diseases. Various antimicrobial agents have become one of the treatment options in the fight against these diseases. With the increase in the number of resistant microorganisms, existing agents became ineffective and there was a need to synthesize or produce new antibiotics, antiparasitic, antiviral and antifungal drugs. There are many studies showing that Schiff base derivatives have antimicrobial properties and proving the existence of their biological activities. In this study, it was aimed to determine the antimicrobial activity of two originally synthesized compounds, a triazole-containing Schiff base, against 16 different bacterial isolates and one different Leishmania species. Methods: In our study, the biological activities of two different newly synthesized triazole-containing Schiff base derivatives against selected one Leishmania and 16 bacteria species were evaluated by the microdilution broth (alamar blue added) method. In the study, the in vitro antibacterial activities of the compounds were determined by measuring their Minimum Inhibitory Concentration (MIC) values. Results: Leishmanicidal activity of Leishmania infantum parasite was determined by measuring its Leishmanicidal Concentration. The compounds were found to have antimicrobial activity against bacteria and parasite at different concentrations. Conclusion: It was concluded that the in vitro antimicrobial activity results obtained in our study will be of significant benefit to future research due to the resistance detected against drugs used in the treatment of infectious diseases and health problems arising due to the side effects of the drugs. If in vivo animal experiments and toxicity studies are as expected; We believe that the in vitro antimicrobial activity results obtained in our study will make a significant contribution to future research due to the resistance detected against drugs used in the treatment of infectious diseases and the health problems caused by their side effects.