Potential interactions between direct oral anticoagulants and atorvastatin/simvastatin: a cohort and case-crossover study
This study shows no evidence of interaction between DOACs and atorvastatin/simvastatin. However, people starting a DOAC while taking atorvastatin/simvastatin were at high risk of bleeding and mortality, likely because of temporal clinical vulnerability.
Authors
- Charlotte Warren‐Gash (ORCID: https://orcid.org/0000-0003-4524-3180)
- Angel Y. S. Wong (ORCID: https://orcid.org/0000-0002-8618-7333)
- Liam Smeeth (ORCID: https://orcid.org/0000-0002-9168-6022)
- Krishnan Bhaskaran (ORCID: https://orcid.org/0000-0001-5364-8757)
- Ian Douglas (ORCID: https://orcid.org/0000-0002-8970-1406)
- Amitava Banerjee (ORCID: https://orcid.org/0000-0001-8741-3411)
- Clémence Leyrat (ORCID: https://orcid.org/0000-0002-4097-4577)
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- Farr Institute (GB)
- University College London (GB)
Publication Details
- Journal
- British Journal of General Practice
- Published
- 2024-11-28
- DOI
- https://doi.org/10.3399/bjgp.2024.0349
- Citations
- 3
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- UK Research and Innovation
- National Institute for Health and Care Research
- British Heart Foundation
- Diabetes UK
- Innovation and Technology Commission
- Medical Research Council