Targeting Metabolomics in Primary Hypertrophic Osteoarthropathy: Uncovering Novel Insights into Disease Pathogenesis
Our study indicated a significant perturbation in oxylipin metabolism among patients with PHO, with distinct metabolic signatures observed between PHOAR1 and PHOAR2. The disruption extended beyond the metabolism of PGE2. It encompassed a broader alteration across the polyunsaturated fatty acid metabolism spectrum, including various eicosanoids and oxylipins. Our work provided a comprehensive understanding of the pathogenesis of PHO, and underscored the potential for subtype-specific therapeutic interventions.
Authors
- Yiyi Gong (ORCID: https://orcid.org/0000-0002-5400-9524)
- Xiaoping Xing (ORCID: https://orcid.org/0000-0002-2759-5177)
- Weibo Xia (ORCID: https://orcid.org/0000-0001-7768-5536)
- Yan Jiang (ORCID: https://orcid.org/0000-0003-4434-3462)
- Ruizhi Jiajue (ORCID: https://orcid.org/0000-0002-3796-8440)
- Xuan Qi (ORCID: https://orcid.org/0000-0001-9441-0841)
- Mei Li (ORCID: https://orcid.org/0000-0001-8634-2252)
- Li Zhang (ORCID: https://orcid.org/0000-0002-1740-8833)
- Ou Wang (ORCID: https://orcid.org/0000-0002-0395-8789)
- Yue Chi (ORCID: https://orcid.org/0009-0002-7337-9982)
- Qianqian Pang (ORCID: https://orcid.org/0000-0002-4028-5560)
- Lijia Cui (ORCID: https://orcid.org/0000-0002-9929-340X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1210/clinem/dgae737
- Citations
- 2
- Primary Topic
- Hypertrophic osteoarthropathy and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Beijing Municipal Natural Science Foundation
- National Key Research and Development Program of China