Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging
Our findings reveal that cell size is a predominant biophysical regulator of MSC localization in vivo compared to adhesion capacity, providing crucial insights to guide optimization of MSC delivery strategies for enhanced therapeutic efficacy.
Authors
- Guangji Wang (ORCID: https://orcid.org/0000-0002-0777-3896)
- Yong Zhong (ORCID: https://orcid.org/0000-0003-2520-0087)
- Junjie Yan (ORCID: https://orcid.org/0000-0001-8016-2277)
- Xin Ji (ORCID: https://orcid.org/0000-0002-5485-3223)
- Min Yang (ORCID: https://orcid.org/0000-0001-6976-8526)
- Tiannv Li
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-9167-2077)
- Jing Wang (ORCID: https://orcid.org/0000-0002-6326-4869)
- Chongyang Chen (ORCID: https://orcid.org/0000-0001-6856-3430)
- Lizhen Wang
- Yuping Xu (ORCID: https://orcid.org/0000-0002-2034-1086)
- Lijun Tang
- Donghui Pan
- Qian Xu
Institutions
- Jiangsu University (CN)
- China Pharmaceutical University (CN)
- Key Laboratory of Nuclear Radiation and Nuclear Energy Technology (CN)
- Jiangsu Province Hospital (CN)
- Viva Biotech (China) (CN)
- State Key Laboratory of Natural Medicine
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s13287-024-04078-4
- Citations
- 11
- Primary Topic
- Tissue Engineering and Regenerative Medicine
- Type
- article
- Field-Weighted Citation Impact
- 6.30
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province