Inhibition of the E3 ligase UBR5 stabilizes TERT and protects vascular organoids from oxidative stress
Inhibiting UBR5 stabilizes TERT, which preserves EPC angiogenic capacity, reduces VO impairment, and delays endothelial cell senescence under oxidative stress. These findings highlight the potential of targeting UBR5 to enhance vascular health in oxidative stress-related conditions.
Authors
- Yuhan Ma (ORCID: https://orcid.org/0000-0001-9768-9171)
- Rui Jin (ORCID: https://orcid.org/0000-0003-4544-6535)
- Nian Cao
- Haijing Zhao
- Weini Li
- Cheng Long (ORCID: https://orcid.org/0000-0001-6806-8405)
- Zhengfeng Wu (ORCID: https://orcid.org/0009-0009-6785-1348)
- Yingyue Zhang (ORCID: https://orcid.org/0000-0002-2056-2946)
- Yuqi Liu (ORCID: https://orcid.org/0000-0001-5792-5723)
- Zheng Li (ORCID: https://orcid.org/0000-0002-2978-2531)
- Honghong Zhang (ORCID: https://orcid.org/0000-0003-1942-9598)
- Yundai Chen (ORCID: https://orcid.org/0000-0003-2252-8992)
- Yue Zhu (ORCID: https://orcid.org/0000-0003-2490-6029)
- Zengao Yang (ORCID: https://orcid.org/0009-0008-0257-723X)
- Huiying Lai
- Qi Liu (ORCID: https://orcid.org/0009-0002-0475-3424)
Institutions
- Cedars-Sinai Medical Center (US)
- National Kidney Foundation (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Biocytogen (China) (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1186/s12967-024-05887-0
- Citations
- 7
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Beijing Nova Program
- National Key Research and Development Program of China