Diosgenin Improves Lipid Metabolism in Diabetic Nephropathy via Regulation of miR-148b-3p/DNMT1/FOXO1 Axis
Dio treatment reduced TG production and lipid droplet formation in HK-2 cells during the progression of DN by modulating the miR-148b-3p/DNMT1/FOXO1/SREBP-2 axis. This finding provides new evidence supporting the therapeutic potential of Dio for DN.
Authors
- J.Y. Yang
- Qinghu He (ORCID: https://orcid.org/0000-0002-4170-3824)
- Wen Sheng (ORCID: https://orcid.org/0000-0001-8053-2434)
- Chengxiong Lin (ORCID: https://orcid.org/0000-0001-8375-207X)
- Zongren Hu
- Dian Li (ORCID: https://orcid.org/0000-0002-5374-7314)
- Jichang Yang
- Min Luo (ORCID: https://orcid.org/0000-0003-3284-629X)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- The Nephron journals/Nephron journals
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1159/000541690
- Citations
- 2
- Primary Topic
- Phytochemical Studies and Bioactivities
- Type
- article
- Field-Weighted Citation Impact
- 0.47