Triglyceride-glucose index and its additive interaction with <i>ABCG2/SLC2A9</i> polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study
The impact of genetic predisposition on hyperuricemia was significantly greater among individuals with a higher TyG index. Over 50% of the increased risk can be attributed to the interaction, indicating a crucial synergy between genetic factors and TyG index when estimating hyperuricemia risk.
Authors
- Huijing He (ORCID: https://orcid.org/0000-0002-2922-752X)
- Minying Zhang
- Qian Cheng (ORCID: https://orcid.org/0000-0003-4362-5783)
- Guangliang Shan (ORCID: https://orcid.org/0000-0002-4535-8941)
- Shuo Chen (ORCID: https://orcid.org/0000-0002-1087-9974)
- Qiang Li (ORCID: https://orcid.org/0000-0002-4384-8226)
- Jingbo Zhang (ORCID: https://orcid.org/0000-0002-6724-8161)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nankai University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1080/07853890.2024.2434186
- Citations
- 8
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China