Mechanism of HIF-1α promoting proliferation, invasion and metastasis of nasopharyngeal carcinoma by regulating MMP-2 in hypoxic microenvironment
HIF-1α could inhibit the proliferation, invasion and metastasis of nasopharyngeal carcinoma by regulating the expression of MMP-2, thus inhibiting tumor growth. Therefore, HIF-1α and MMP-2 might become important therapeutic targets to inhibit the growth, invasion and metastasis of nasopharyngeal carcinoma.
Authors
- Yi Ren (ORCID: https://orcid.org/0000-0002-0176-493X)
- Ying Lan
- Jun Tang
- Tao Hou (ORCID: https://orcid.org/0000-0001-8158-8114)
- Shijie Zhao (ORCID: https://orcid.org/0009-0004-6430-0253)
- Shihua Yin (ORCID: https://orcid.org/0000-0002-1184-1978)
- Yang Wu
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e40760
- Citations
- 4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi
- Guangxi Key Research and Development Program