Treatments of transarterial chemoembolization (TACE), stereotactic body radiotherapy (SBRT) and immunotherapy reshape the systemic tumor immune environment (STIE) in patients with unresectable hepatocellular carcinoma
STIE cells are significant for treatment response, can be reshaped differentially after TACE, SBRT, and IO. The most significant changes of T-lymphocyte lineage are SBRT associated modulations in CD25<sup>+</sup>CD8<sup>+</sup> T cells, CD127<sup>+</sup>CD8<sup>+</sup> T cells, and NKT cells, which also have significant effects on the ultimate treatment response after TACE-SBRT-IO (ClinicalTrails.gov identifier: GCOG0001/NCT05061342).
Authors
- Danyang Zheng (ORCID: https://orcid.org/0000-0003-1526-7560)
- Chung Mau Lo (ORCID: https://orcid.org/0000-0002-3964-5995)
- Wan-Hang Keith Chiu
- Chi‐Leung Chiang (ORCID: https://orcid.org/0000-0002-9836-6478)
- Ji Ren (ORCID: https://orcid.org/0000-0002-1970-7423)
- Carmen W.H. Chan (ORCID: https://orcid.org/0000-0003-0696-2369)
- Feng‐Ming Kong (ORCID: https://orcid.org/0000-0003-2652-098X)
- C. Li (ORCID: https://orcid.org/0000-0003-1178-5520)
- Weiwei Chen (ORCID: https://orcid.org/0000-0003-2289-3578)
- Cai‐Ning Zhao
- Wenqi Chen (ORCID: https://orcid.org/0000-0002-5348-2977)
- Salma K. Jabbour (ORCID: https://orcid.org/0000-0001-9287-6007)
- Sik-Kwan Chan
Institutions
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Queen Elizabeth Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of the National Cancer Center
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.jncc.2024.06.007
- Citations
- 6
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- University of Hong Kong
- Hong Kong Polytechnic University
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Shenzhen Fundamental Research Program