Pyropheophorbide-α methyl ester-mediated photodynamic therapy triggers pyroptosis in osteosarcoma cells via the ROS/caspase-3/GSDME pathway
MPPa-PDT can induce pyroptosis in osteosarcoma cells, which has the effect of enhancing apoptotic processes. Mitochondrial damage and ROS/caspase-3/GSDME pathway are the possible mechanisms of pyroptosis induced by MPPa-PDT.
Authors
- Yunsheng Ou
- Qiu Huang (ORCID: https://orcid.org/0000-0002-2966-6450)
- Yuxing Chen (ORCID: https://orcid.org/0009-0000-0347-1789)
- Fuqiang Tan (ORCID: https://orcid.org/0000-0002-0194-958X)
- Ye Zhang (ORCID: https://orcid.org/0009-0000-4883-8097)
- Tao Yong (ORCID: https://orcid.org/0000-0002-3346-6937)
Institutions
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104427
- Citations
- 1
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing