Management of hemolytic transfusion reactions in a patient with chronic myelomonocytic leukemia and rare antibodies: A case report
Delayed hemolytic transfusion reaction (DHTR) poses a significant challenge in patients receiving blood transfusions. This case report highlights the complexities of managing DHTR in a newly diagnosed chronic myelomonocytic leukemia (CMML) patient with clinically significant JKa and little c antibodies during induction chemotherapy. A 46-year-old woman with CMML-2 who presented for induction chemotherapy was found to have hemolytic anemia. Due to presence of JKa and little c antibodies, she required intensive monitoring and supportive care measures. The coexistence of JKa and little c antibodies complicates transfusion management and chemotherapy tolerance in CMML patients.
Authors
- Courtney Denton Dinardo (ORCID: https://orcid.org/0000-0001-9003-0390)
- Effrosyni Apostolidou
- Himachandana Atluri (ORCID: https://orcid.org/0000-0002-8867-7774)
- Maryam Buni
- Guillermo Montalban‐Bravo (ORCID: https://orcid.org/0000-0002-4533-5176)
- Grace S. Park (ORCID: https://orcid.org/0000-0002-2075-5502)
- Naveen Pemmaraju (ORCID: https://orcid.org/0000-0002-1670-6513)
- Jiří Horák
- Bryan Guillroy
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Leukemia Research Reports
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.lrr.2024.100485
- Citations
- 1
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- University of Texas MD Anderson Cancer Center