Effect of N-acetylcysteine on apoptosis and autophagy of macrophages infected with Mycobacterium tuberculosis
MTB infection can lead to an increase in macrophage OS, apoptosis, and autophagy levels. However, after treatment with NAC, the growth of MTB in macrophages is inhibited, and OS and autophagy levels are reduced. The antioxidant effect and inhibitory effect of NAC on MTB are related to MTB-mediated macrophage OS and autophagy.
Authors
- Yu Pang (ORCID: https://orcid.org/0000-0001-6803-9807)
- Lihui Nie
- Tianhui Gao
- Renchun Su (ORCID: https://orcid.org/0000-0001-9457-6817)
- Shanshan Li (ORCID: https://orcid.org/0009-0003-1022-4665)
- Qi Li (ORCID: https://orcid.org/0000-0002-6165-2489)
- Min Qiao (ORCID: https://orcid.org/0000-0001-7379-353X)
- Jingtao Gao (ORCID: https://orcid.org/0000-0002-0221-9730)
- Yufeng Wang
Institutions
- Shanxi Medical University (CN)
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Beijing Chest Hospital (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- The Journal of Infection in Developing Countries
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3855/jidc.19372
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Major Science and Technology Projects of China