Clinical epidemiology, genetic diversity, and drug susceptibility patterns by whole genome sequencing of Mycobacterium tuberculosis complex isolates in Gabon from 2012 to 2022
Although most Mtbc infections are caused by L4 <i>M. tuberculosis</i> strains, <i>M. africanum</i> strains also contribute to TB epidemiology in Gabon. The MDR epidemic is mainly driven by one dominant L4 Haarlem outbreak clone that has been spreading for approximately a century in the country.
Authors
- Bayodé Roméo Adégbitè (ORCID: https://orcid.org/0000-0003-4208-6212)
- Micheska Epola Dibamba Ndanga (ORCID: https://orcid.org/0009-0006-9810-962X)
- Rhett Chester Mevyann
- Christopher Mebiame Biyogho
- Abraham Alabi (ORCID: https://orcid.org/0000-0003-0324-6420)
- Viola Dreyer (ORCID: https://orcid.org/0000-0003-2997-3693)
- Stefan Niemann
- Jean Ronald Edoa (ORCID: https://orcid.org/0000-0003-1594-9510)
- Andrea Rosine Omera Obele Ndong
- Peter G. Kremsner
- Fabrice Beral M’Baidiguim
- Martin P. Grobusch
- Ayôla Akim Adégnika (ORCID: https://orcid.org/0000-0003-3197-5946)
- Jabar B P A A Agbo
- Guy A R I Mfoumbi
Institutions
- University of Cape Town (ZA)
- Leiden University Medical Center (NL)
- Centre de Recherche Médicales de Lambaréné (GA)
- German Center for Infection Research (DE)
- Research Center Borstel - Leibniz Lung Center (DE)
- Amsterdam University Medical Centers (NL)
- University of Tübingen (DE)
- University of Amsterdam (NL)
Publication Details
- Journal
- IJID Regions
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.ijregi.2024.100501
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.78
Funders
- Deutsches Zentrum für Infektionsforschung
- Max-Planck-Gesellschaft
- European and Developing Countries Clinical Trials Partnership