International Poster Session

BackgroundContemporary literature suggests that advanced cancer negatively impacts QOL.Few studies have(1)examined how QOL changes in CRC patients over the first year of treatment and (2) compared longitudinal QOL between patients with earlier(stage I, II)versus advanced(stage III, IV)disease.Methods 227 CRC patients were recruited at diagnosis and followed-up until 12 months post-surgery.Patients completed the EORTC QLQ-C30 at baseline, 1-month, 3-month, 6-month, and 12-month.Demographic and clinical data were extracted from electronic medical records.Results 111(48.9)patientshad advanced CRC.The advanced group was younger (mean age 65.9 versus 69.2 years) and most needed chemotherapy(N=9182.0)compared to the earlier group.Advanced group experienced lower global QOL, physical, role, and social functioning after 1-month timepoint compared to earlier CRC.However, multilevel mixed-effects regression suggested that CRC staging was not significantly associated with change in QOL scores longitudinally.Conclusions Patients with advanced CRC may not experience poorer QOL than those with earlier stage.QOL over the treatment course likely to be influenced by baseline QOLfurther mixed-methods approaches should explore pre-existing patient factors indicating impaired QOL. Cancer stagingQuality of life !IP-6E Quality-of-life over the first 12 months post- surgery for colorectal cancer patients requiring stoma