Synthesis and application of poly(amidoamine) functional biomedical materials in the field of biomedicine over the past decade

Abstract Over the past decade, significant advancements have been achieved in the field of biomedicine, particularly in the treatment of critical illness. However, there remain numerous challenges and barriers persist in drug delivery, medical imaging, diagnosis, and treatment. Poly(amidoamine) (PAMAM) dendrimers have emerged as promising candidates for the development of functional biomedical materials due to their advantageous properties, including ease of preparation, controllable size, abundant cavities, water solubility, modifiability, and biocompatibility. This article presents a comprehensive review of the synthesis, application, and potential toxicity of PAMAM functional biomedical materials, exploring the role, significance, and potential applications of PAMAM dendrimers in detail. The aim is to provide a valuable reference for the future development of biomedical materials and to inspire further discoveries in the field of polyamide functional materials.