Substitution of Glutamic Acid at Position 71 of <scp><i>DRβ1</i></scp>*04:01 and Collagen‐Specific Tolerance Without Alloreactivity
These studies demonstrate that editing a single amino acid in DRβ1*04:01 blocks collagen peptide binding without inducing alloreactivity and could therefore represent a gene therapy approach to induce antigen-specific passive tolerance.
Authors
- Brian M. Freed (ORCID: https://orcid.org/0000-0002-1542-1313)
- Edward F. Rosloniec (ORCID: https://orcid.org/0000-0001-6225-5867)
- Vibha Jha
- Amy S. McKee (ORCID: https://orcid.org/0000-0002-9268-5574)
- Christina L. Roark (ORCID: https://orcid.org/0000-0002-2598-2093)
- Marilyne Coulombe (ORCID: https://orcid.org/0000-0002-3508-0368)
- Jennifer L. Matsuda (ORCID: https://orcid.org/0000-0002-9191-9893)
- Manjula Miglani
- Elizabeth R. Sunderhaus
- Edward B. Prage
- Jessica E. Lee (ORCID: https://orcid.org/0000-0002-5626-4297)
Institutions
- University of Tennessee Health Science Center (US)
- National Jewish Health (US)
- Memphis VA Medical Center (US)
- Gene Therapy Laboratory (FR)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/art.43067
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Jewish Health
- Anschutz Medical Campus, University of Colorado