Rh(II)‐Catalyzed Tandem Reaction of 2‐Trimethylsiloxy‐pyridine and <i>α</i>‐Trifluoromethyl Diazomethane: An Approach to Tetrasubstituted <i>gem</i>‐Difluoro Olefins
Abstract Herein, we describe a Rh 2 (OAc) 4 ‐catalyzed reaction of 2‐trimethylsiloxy‐pyridine and fluorinated diazomethanes, which provides an effective and straightforward approach to the synthesis of 2‐oxopyridinyl tetrasubstituted gem ‐difluoro olefins. This protocol features good functional group compatibility, mild reaction conditions, good yield, and readily available substrates.
Authors
- Xuefei Zhao (ORCID: https://orcid.org/0000-0002-8651-6248)
- Shengchao Yang (ORCID: https://orcid.org/0000-0002-4362-6578)
- Guanghui Li (ORCID: https://orcid.org/0000-0001-8835-8346)
- Lu Liu (ORCID: https://orcid.org/0000-0003-2151-891X)
- Xinyu Huang (ORCID: https://orcid.org/0000-0002-4260-9952)
- Jia Lv (ORCID: https://orcid.org/0000-0001-9330-1635)
Institutions
- Shihezi University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/ejoc.202400899
- Citations
- 1
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.21