SS31 alleviates LPS-induced acute lung injury by inhibiting inflammatory responses through the S100A8/NLRP3/GSDMD signaling pathway
The research results indicate that SS31 may inhibit the activation of the NLRP3 inflammasome and suppress inflammatory responses by regulating S100A8, thereby alleviating LPS-induced ALI in mice; this process may be related to pyroptosis.
Authors
- Quankuan Gu
- Nana Li (ORCID: https://orcid.org/0009-0002-1759-2295)
- Xianyong Li (ORCID: https://orcid.org/0000-0003-4118-6203)
- Peiyao Luo (ORCID: https://orcid.org/0000-0002-7284-4048)
- Xianglin Meng (ORCID: https://orcid.org/0000-0001-5091-3260)
- Jianpeng Wang (ORCID: https://orcid.org/0000-0002-7488-2005)
- Wei Yang (ORCID: https://orcid.org/0009-0000-7388-5354)
- Mingyan Zhao (ORCID: https://orcid.org/0000-0003-4287-8586)
Institutions
- Harbin Medical University (CN)
- Education Department of Heilongjiang Province (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-11-29
- DOI
- https://doi.org/10.1186/s40001-024-02169-9
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China