The Effects of Pregnancy on Disease Progression of Retinitis Pigmentosa
This is the first large-scale objective study analyzing the effects of pregnancy in genetically-confirmed women with RP. Women with USH2A-associated RP who had children appeared to have 3.04 times the risk of reaching VA below 20/100 than those who did not have children. It is possible that other factors besides retinal degeneration are affecting central vision and causing this increased risk. A significant association between faster or slower EZ loss and pregnancy was not present in our cohort. We believe these findings will be relevant to all women with RP considering starting a family; although further studies are needed.
Authors
- Andre Lopes (ORCID: https://orcid.org/0000-0002-1405-7337)
- Michel Michaelides (ORCID: https://orcid.org/0000-0002-1552-7046)
- Malena Daich Varela (ORCID: https://orcid.org/0000-0003-4960-4510)
- Memuna Rashid (ORCID: https://orcid.org/0009-0004-0596-8560)
Institutions
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- Moorfields Eye Hospital (GB)
- University College London (GB)
Publication Details
- Journal
- American Journal of Ophthalmology
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1016/j.ajo.2024.11.016
- Citations
- 3
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- Wellcome Trust
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Moorfields Eye Hospital NHS Foundation Trust
- UCL Institute of Ophthalmology, University College London