Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset
Steeper rates of increase in pTau and GFAP among amyloid-positive individuals. After amyloid onset, steeper increases in pTau and NfL concentrations in men than in women. Steeper declines in brain volume and cognition in men corroborate biomarker results.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- Przemysław Radosław Kac (ORCID: https://orcid.org/0000-0001-5083-0924)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Thomas K. Karikari (ORCID: https://orcid.org/0000-0003-1422-4358)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Madhav Thambisetty (ORCID: https://orcid.org/0000-0002-2200-2299)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Murat Bilgel (ORCID: https://orcid.org/0000-0001-5042-7422)
- Cassandra M Joynes
- Yang An
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- Johns Hopkins University (US)
- King's College London (GB)
- Johns Hopkins Medicine (US)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Centre for Mental Health (GB)
- UK Dementia Research Institute (GB)
- National Institute on Aging (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-28
- DOI
- https://doi.org/10.1002/alz.14405
- Citations
- 13
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.01
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- National Institutes of Health
- HORIZON EUROPE Framework Programme
- National Institute on Aging